Pain Pod

COVID Keto Guido | PAIN POD

On this episode of the PAIN POD, Mark Pain Guy Garofoli will take you on a journey of a pain guy in pain, and just what our patients hear from us as healthcare professionals, and what the healthcare system experience can be like when not being the one wearing the stethoscope, and rather being the patient in pain.
Can anyone imagine being dropped off at the ER by your Wife and toddler on Friday the 13th during a pandemic to only begin a 3 month long excruciating journey of pain? Pain Guy Garofoli can tell you all about it, and provide a few clinical pearls to improve patient care along the way! This is not a campfire conversation, but you can feel free to download and listen while camping, swimming, biking, walking, or however, you’d like, just be forewarned that Mark will not be sparing any painful details. You’re welcome and he’s sorry, all at once!
COVID & NSAIDs Info
https://www.bbc.com/news/51929628
Jeong HE, et al. Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study. Clin Infect Dis. 2020 Jul 27.
https://clinicaltrials.gov/ct2/show/record/NCT04334629
NSAID COX-1 & COX-2 Studies
Feldman, M, et al. Do Cyclooxygenase-2 Inhibitors Provide Benefits Similar to Those of Traditional Nonsteroidal Anti-Inflammatory Drugs, with Less Gastrointestinal Toxicity. Ann Intern Med. 2000; 132: 134-143
Herndon, C. et al. Management of Chronic Nonmalignant Pain with Nonsteroidal Anti-inflammatory Drugs. Pharmacotherapy. 2008; 28 (6): 788-805.
Masso Gonzalez EL, et al. Variability among nonsteroidal anti-inflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum 2010; 62: 1592-601.
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The Pharmacist - Dan Schneider | PAIN POD

How many times a day are YOU asked if you’re the pharmacist? Countless!
Well join us in this episode of the PAIN POD while Mark “Pain Guy” Garofoli chats with literally THE Pharmacist, Dan Schneider, famous for all of his amazing efforts within the Opioid Crisis, as highlighted on the Netflix series “THE Pharmacist”.
Every 7 minutes an American dies of a drug overdose, and that’s soon to be every 5 or 6 minutes based on upcoming data confirmation. Conversely, every 30 minutes a baby is born dependent, not addicted, to opioids. Headline after headline sensationalizes a reality that many times heroin utilizers begin their respective diacetylmorphine (that’s Heroin folks!) utilization via prescription opioids. Check out this JAMA article as the foundation for so very many headlines: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1874575.
Dan Schneider’s life work, and “story”, were first highlighted in this article: https://www.nola.com/news/crime_police/article_934b7d20-a78a-535a-8691-26cfc7f9bee7.html, and he joins us in this podcast to dive much, much deeper into the saga, culminating with avenues for all of us to join the efforts, via his “Tunnel of Hope” organization: https://tunnelofhope.org/.
How did we get into the “War on Drugs”, or perhaps better yet, how in the world do we get ourselves out? There’s 330 million Americans waking up everyday, living day in and day out as the solution. If every one of us helped one person, imagine the world.
So listen in to this episode of the PAIN POD now, to hear THE Pharmacist chat with the Pain Guy, in an effort to do just that, help save and improve lives, one at a time!
This episode is sponsored by the Ultiguard Safe Pack. UltiGuard Safe Pack is the only pen needle product that comes with an all-in-one sharps container. Learn more about why UltiGuard Safe Pack is the best choice for your patients and your pharmacy., 
Learn more about the UltiGuard Safe Pack: 
https://www.ulticare.com/ultiguard-safe-pack/podcast
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Opioid Madness Part Two | PAIN POD

March Madness inspired us, and our audience has waited long enough. What better time, than during a pandemic, to dive into “OPIOID MADNESS” and crown “The Greatest Opioid of All Time”!!!
In this episode of the “PAIN POD”, Mark “Pain Guy” Garofoli will continue the conversation from Opioid Madness Part 1, the opioid bracketology, or perhaps an “Opioidology”, but definitely a whole bunch of “Opioid Madness”. The battle of poppy versus poppy, and of course a bunch of man-made opioid opponents as well. Cool names and fancy formulations only get one so far, and we simply have no room for bias, thus pharmacology will rule as law of the land, to ultimately crown, “THE GREATEST OPIOID OF ALL TIME”.
The blood thirsty, constipating, yet definitely not sedating championship opioid brawl continues. One opioid, an opioid of all opioids, will remain standing atop the mountain of Mu, declaring its victory over all other opioids from all lands near and far. Which opioid will it be? The PAIN POD crowns the champ!
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Opioid Madness Pt. 1 | PAIN POD

March Madness is upon us, and what better time, than during a pandemic, to dive into “OPIOID MADNESS”!!!
 
In this episode of the “PAIN POD”, Mark “Pain Guy” Garofoli will talk us through an opioid bracketology, perhaps an “Opioidology”, but definitely a whole bunch of “Opioid Madness”, in order to pit one opioid against another. A battle of poppy versus poppy, and of course a bunch of man-made opioid opponents as well. Cool names and fancy formulations only get one so far, and we simply have no room for bias, thus pharmacology will rule as law of the land, to ultimately crown, “THE GREATEST OPIOID OF ALL TIME”.
 
We’ll start with a “Sweet 16” of opioids, mention a few bubble busting first four out, and navigate our way through the “Elite 8” and “Final 4” to culminate in a blood thirsty, constipating, yet definitely not sedating championship opioid brawl. One opioid, an opioid of all opioids, will remain standing atop the mountain of Mu, declaring its victory over all other opioids from all lands near and far. Just as Rocky Balboa declared his presence on top of the mountains of Russia, there will remain one opioid for all ages. Yet, all this opioid bracketology madness may not be the main point after all, tune in today to enjoy a brief journey through all things opioids, and learn more about what this madness is actually all about. Let the brackets begin!!!
 
To get amped up for this “PAIN POD” episode, checkout Rocky training for “OPIOID MADNESS” in Russia via this Fandango Movie Clip: https://www.youtube.com/watch?v=hHC_R7ATGuI (No anabolic steroids were used in the development of this episode, as we have learned from Drago that cheaters never win!)
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Mark Garofoli, PharmD | PAIN POD

PAIN POD EPISODE 0
One of the most common definitions of pain describes pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.” When we are exposed to something that causes pain, if able, we quickly or reflexively withdraw. The sensory feeling of pain is called nociception.
What Does It Mean to Call Chronic Pain a Brain Disease? by Mark D. Sullivan
https://www.jpain.org/article/S1526-5900(12)00560-3/pdf
Multiple investigators have recently asked whether neuroimaging has shown that chronic pain is a brain disease. We review the clinical implications of seeing chronic pain as a brain disease. Abnormalities noted on imaging of peripheral structures have previously misled the clinical care of patients with chronic pain. We also cannot assume that the changes associated with chronic pain on neuroimaging are causal. When considering the significance of neuroimaging results, it is important to remember that ‘‘disease’’ is a concept that arises out of clinical medicine, not laboratory science.
Our Host:
Mark Garofoli, PharmD
Clinical Assistant Professor
WVU School of Pharmacy (Department of Clinical Pharmacy)
WV School of Pharmacy curriculum education in areas of expertise such as pain management, substance-use disorder, medication therapy management, managed care, geriatric care, management, leadership, and experiential learning.
Brian Regan - The Emergency Room
https://youtu.be/d2Vg3iSd5ms
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